Articles in journal publications
We are proud to continue our work with the mistletoe as well as studies on rhythms and potencies of substances in a manner that both emphasizes the presence of the “spirit forces in matter” (Kolisko motto) but is also recognized to have high standards in the scientific community.
For more of our research go here.
Below are the six studies to date:
- Pilot Study: New Aqueous Extracts of the Mistletoe (Viscum Album L.) Plant, Diminish In Vitro Cell Proliferation of The NSCLC Cell Line with EGFR Mutations HCC 827
Abstract
Non-small cell lung adenocarcinoma with EGFR mutations continues to be a vexing problem due to the ability of the cancer to rapidly develop drug resistance. In vitro studies with the non-small cell lung adenocarcinoma cell line HCC827 (with an acquired mutation in the EGFR tyrosine kinase domain, E746 – A750 deletion) are relevant to the finding of increasingly effective treatments. Pharmaceutically processed extracts of mistletoe, Viscum album Loranthaceae, have been shown since the 1920’s to have potential in cancer therapy. They are currently the most frequently used natural preparations in complementary cancer treatments. In this pilot study we demonstrate that newly prepared standardized extractions of mistletoe (Viscum album, L.), from different host trees, are shown to significantly diminish the cell proliferation of the HCC 827 cell line.
Authors: R. Rentea, M.Kamsler, M. Mueller
DOI: 10.19080/CTOIJ.2023.25.556160
- Therapeutic applications of Viscum Robinia RK 30X
Abstract
The spiritual significance of the robinia tree and the mistletoe (Viscum album L.) growing on the robinia tree can be better understood if the anthroposophic interpretation supported by botany, mythology and other healing systems is considered. Viscum Robinia Kolisko (RK) in its potentized form, dispensed orally, has been found helpful to strengthen the soul life of those patients who have lost faith in the possibility of healing, are overcome by worries, cannot let go of previous trauma, feel unable to go on and to persevere in spite of life’s challenges. This soul condition is frequently connected to digestive disturbances. Five clinical cases are presented.
Authors: R. Rentea, M.Kamsler
https://doi.org/10.14271/DMS-21763-EN
- Pilot Study: Evidence that High and Ultra-high Diluted Extracts of the anti-tumor active Mistletoe (Viscum Album L.) Plant Inhibit but may also Stimulate in Vitro Cell Proliferation of K562 Leukemia Cells
Abstract
Mistletoe extracts are widely used in Central Europe, as well as world-wide, as an adjuvant cancer therapy. In the laboratory, high doses of mistletoe extracts are largely considered to be uniformly inhibiting on cell proliferation in vitro. Some controversy has arisen however whether low doses of mistletoe extracts can be also stimulating and thus whether clinical low doses of mistletoe should be more cautiously administered in a clinical setting. We provide evidence that not only low but also highly and ultra-highly diluted extracts of mistletoe can both inhibit as well as stimulate in vitro cell proliferation.
DOI: 10.19080/CTOIJ.2024.25.556204
- Pilot study: rhythmical behavior of ultra-high potencies of substances in cell cultures
Abstract
Research in the hormetic field has demonstrated a bi -phasic dose response in substances such that a high dose of a substance being inhibiting/toxic can have an opposite effect at a low dose where it becomes stimulating. Hormesis confines itself to measurable levels of the substances/stressors. However, homeopathic research has shown that these bi-phasic enantiodromic effects of substances occur even at ultra -high dilutions (potencies), beyond log 24. In 1923 R. Steiner and L. Kolisko demonstrated a new phenomenon in which the enantiodromic effects alternate semi-sinusoidally between inhibiting and stimulating activities. We have studied this phenomenon in several substances in cell cultures, confirm Kolisko’s and R. Steiner’s findings and discuss the significance of this rhythmical phenomenon. The mechanistic explanation is still to be elucidated but anthroposophical insights give a path to a more comprehensive understanding.
Authors: R. Rentea, M.Kamsler, M. Mueller
https://doi.org/10.14271/DMS-21805-EN
- Moon transits against the backdrop of different sidereal constellations affect the growth of various in vitro cell cultures: a pilot study
Abstract
Multiple scientific studies have reported that the lunisolar gravitational forces causing tidal accelerations on the Earth influence the physiology and behavior of diverse life forms through embedded genetic timers. These cyclical clocks are also influenced by the periodic light changes of the Moon phases. Aside from experimentation with simulated star light no connection has been demonstrated in the natural environment to the far planets or stars. An exception to this constitutes the work of M. Thun who in decades of observations demonstrated that Moon transits through sidereal constellations can affect vegetable crops. We hypothesized that cell cultures would behave similarly to plants and would show an enhanced growth/proliferation when the Moon transited some constellations and not through others. K562 and HCC827 cells were cultured for 72 hours. The results confirmed that when the cell cultures were started on days when the Moon was in Cancer, Scorpio or Pisces the cell proliferation was significantly increased compared to the proliferation when the cell cultures were started on days when the Moon was in the Taurus, Virgo and Capricorn constellations. We attempt an explanation for this phenomenon that hypothesizes that embedded genetic star responsive timers occur in individual cells.
Authors: Razvan Rentea, Mark Kamsler, Andrea Rentea, Malory Mueller
Accepted for publication in the Merkurstab Journal for February 2025
DOI: https://doi.org/10.14271/DMS-21893-EN
6. The Mother Tincture as well as a High Dilution of proprietary Mistletoe (Viscum album L.) extracts Inhibit the Proliferation of the Prostate Cancer Cell line LNCaP, while Stimulating the Cell Proliferation of the Normal Human Prostate Cell Line RWPE: A Pilot Study
Abstract
Conventional treatments for advanced prostate cancer frequently entail major side effects. These drive patients to seek adjuvant therapies that are more tolerable. Pharmaceutically prepared extracts of mistletoe (Viscum album L.) are very popular and well established as complementary, adjuvant therapies to many cancer interventions, yet studies with mistletoe in prostate cancer are lacking. We have demonstrated that mother tinctures as well as the D23 dilution of proprietary extracts of several sub-species of Viscum album L. can inhibit the in vitro proliferation of the prostate cancer line LNCaP. On the other hand, the growth of the normal prostate cell line RWPE is stimulated. This points towards the potential safe clinical use of these extracts. We also demonstrate that apoptosis is induced by the high dilution D23. Being able to use high dilutions of this therapeutic plant would have significant advantages both for therapeutic purposes as well as for botanical environmental preservation.
Authors: Razvan Rentea, Mark Kamsler, Malory Mueller
Published: March 25, 2025
DOI: 10.19080/CTOIJ.2025.28.556240